World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Validation of Procedures for Monitoring Crewmember Immune Function

By Crucian, Brian

Click here to view

Book Id: WPLBN0004308396
Format Type: PDF eBook :
File Size:
Reproduction Date: 2008-02-04

Title: Validation of Procedures for Monitoring Crewmember Immune Function  
Author: Crucian, Brian
Language: English
Subject: Communication Equipment, Communication Networks, Engine Control
Collections: Government Library Collection, Government Library Collection
Publication Date:


APA MLA Chicago

Peter, U. (2008). Validation of Procedures for Monitoring Crewmember Immune Function. Retrieved from

Description: There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. The clinical risk (if any) from prolonged immune dysregulation during exploration-class space flight has not yet been determined, but may include increased incidence of infection, allergy, hypersensitivity, hematological malignancy or altered wound healing. Each of the clinical events resulting from immune dysfunction has the potential to impact mission critical objectives during exploration-class missions. To date, precious little in-flight immune data has been generated to assess this phenomenon. The majority of recent flight immune studies have been post-flight assessments, which may not accurately reflect the in-flight status of immunity as it resolves over prolonged flight. There are no procedures currently in place to monitor immune function or its effect on crew health. The objective of this Supplemental Medical Objective (SMO) is to develop and validate an immune monitoring strategy consistent with operational flight requirements and constraints. This SMO will assess immunity, latent viral reactivation and physiological stress during both short and long duration flights. Upon completion, it is expected that any clinical risks resulting from the adverse effects of space flight on the human immune system will have been determined. In addition, a flight-compatible immune monitoring strategy will have been developed with which countermeasures validation could be performed. This study will determine, to the best level allowed by current technology, the in-flight status of crewmembers' immune systems. The in-flight samples will allow a distinction between legitimate in-flight alterations and the physiological stresses of landing and readaptation which are believed to alter R0 assessments. The overall status of the immune system during flight (activation, deficiency, dysregulation) and the response of the immune system to specific latent virus reactivation (known to occur during space flight) will be thoroughly assessed. The first in-flight activity for integrated immunity very recently occurred during the STS-120 Space Shuttle mission. The protocols functioned well from a technical perspective, and accurate in-flight data was obtained from 1 Shuttle and 2 ISS crewmembers. Crew participation rates for the study continue to be robust.; CASI; Nasa Publication Center: Johnson Space Center; Unclassified; No Copyright; Unlimited; Publicly available


Click To View

Additional Books

  • Small and Medium Sized Enterprise Progra... (by )
  • Teaching English Language Learners 
  • Customer Satisfaction Measurement Issues... (by )
  • Decorating the Capitol in the Pompeian S... (by )
  • The Okhrana's Female Agents (by )
  • Malawi Primary Education Social Studies (by )
  • The Okhrana's Female Agents Part II : In... (by )
  • Engines and Turbines and Farm Machinery ... (by )
  • United States Department of Commerce Dc ... (by )
  • Understanding the Process of Economic Ch... (by )
  • Analyzing Soviet Politics and Foreign Po... (by )
  • Spheres of Influence the Nexttarget Ofbi... (by )
  • Alice in Wonderland (by )
  • The Power of Our Words (by )
  • Ksiaga Herbowa Rodaw Polskich (by )
  • Slovenský Domáci Lekár a Radca; Ináe, Pr... (by )
  • Encyklopedja Powszechna (by )
  • Insan Ve Din (by )
  • Dutch Fairy Tales for Young Folks (by )
  • Adama Mickiewicza Konrad Wallenrod I Gra... (by )
  • Report of the Children's Commission to t... (by )
  • A History of Animals 
  • Spisy Básnické Andreja Sládkovia (by )
  • Sisters of Glass (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.